From target molecule to ranked pathways in minutes
SYNTHIA® retrosynthesis software generates ranked synthetic pathways using curated reaction knowledge and advanced algorithms. By connecting with Luma, Dotmatics’ scientific decision layer, chemists can evaluate route options alongside real experimental data and prior results—so chemists can move from ranked routes to real decisions without chasing records across disconnected systems.
Enhancing Retrosynthesis With Real Experimental Context
Predictive Route Generation
AI-driven retrosynthesis from a target molecule, powered by SYNTHIA’s curated reaction knowledge.
Experimental Context, Preserved
Evaluate routes alongside lab history, experimental data, and prior decisions, not just algorithmic rankings.
Decisions That Hold Up Over Time
Traceability from route design through execution makes your reasoning as durable as your results.
Connected from prediction to execution
An API-based integration connects SYNTHIA’s predictive engine directly with Luma’s scientific decision layer. Routes generated in SYNTHIA return to Luma where they can be evaluated against your team’s existing data — including prior synthesis attempts, analytical results, inventory, and planning context — so that the path from route design to lab execution is continuous, not fragmented.

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Interested in exploring the SYNTHIA® + Luma workflow with your team? Submit the form below and we’ll reach out to discuss pilot fit and next steps.
Resources
Explore our latest white papers, webinars, and more to stay informed about cutting-edge advancements in AI-powered drug discovery and retrosynthesis.
Videos
Discover how to apply generative AI methods in hit identification, hit-to-lead, and lead optimization of novel molecules.



